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SAM-e vegetarian capsules deliver 200 mg of S-adenosyl-methionine in acid-resistant capsules that provide
both protection and pH targeted release in intestinal fluid. SAM-e has been shown to support
neurotransmitters and mood, methylation, liver health, and joints.†
SAM-e (S-adenosyl-methionine) is a naturally occurring molecule derived from the amino acid methionine.
SAM-e has been shown to be efficacious in supporting numerous aspects of health. SAM-e, as a methyl
donor, participates in a wide variety of biochemical reactions, acts as a precursor molecule for glutathione and
polyamine synthesis, and supports healthy functioning of neurological processes, joints, and the liver.† SAM-e
is a methyl donor in the methylation reactions shown to form monoamine neurotransmitters such as dopamine,
serotonin and norepinephrine. Human studies show SAM-e supports a positive mood and healthy central
nervous system function.† SAM-e is also essential to the development of the phospholipid bilayer that makes
up the outer membranes of normal cells by contributing to phosphatidylcholine production and cellular
membrane fluidity and integrity.†
SAM-e’s joint support lies not only in its ability to help regulate the body’s normal physiological processes, but
also on its putative participation in proteoglycan synthesis and joint cartilage synthesis.
† SAM-e is thought to
function physiologically as a signal of sulfur availability. Some suggest that supplemental S-adenosylmethionine
may compensate for the decreased SAM-e levels in chondrocytes induced by the cytokine
interleukin-1, and thus upregulate the chondrocyte’s synthesis of joint proteoglycans. A randomized control
study of 56 participants taking SAM-e offered statistically significant results for joint comfort.†
As a liver health compound, SAM-e has been shown to support the body’s response to adverse biochemical
alterations induced by lead and/or alcohol exposure.† SAM-e can be an integral part of a liver support regimen
by supporting glutathione levels. Human studies indicate that SAM-e supplementation enhances glutathione
production in hepatic tissue and red blood cells.†
SAM-e vegetarian capsules may be a useful nutritional supplement for individuals desiring support of mood,
joints, methylation, or liver health.†
FORMULA (#202170-60X)
Each Vegetarian Capsule Contains:
S-Adenosyl-methionine (S-Adenosyl-methionine disulfate tosylate) .................. 200 mg
Other ingredients: Capsule (hydroxypropyl methylcellulose, gellan gum, water), microcrystalline cellulose,
calcium oxide, ascorbyl palmitate, calcium chloride.
Adults take 1 capsule, 1-2 times daily between meals or as directed by a healthcare professional.
No adverse side effects have been reported.
Store in a cool, dry place, away from direct light. Keep out of reach of children.

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