Glucoset

Glucoset™
Nutritional Support for Healthy Glucose Metabolism

PRODUCT DATA DOUGLAS LABORATORIES® 04/2012
DESCRIPTION
Glucoset™ capsules, provided by Douglas Laboratories®, contain a complementary blend of thiamin, biotin,
chromium, alpha-lipoic acid, N-acetyl-L-cysteine, and standardized extract of Gymnema sylvestre leaf for
targeted nutritional support of glucose metabolism.
FUNCTIONS
Glycation is the non-enzymatic attachment of sugars to major molecules in the body, including proteins, lipids,
and nucleic acids. Glycation reactions generate advanced glycation end-products (AGE’s) and glycotoxin
intermediates. AGE’s can cause abnormal and destructive functioning of body proteins, lipids, and nucleic
acids. AGE associated damage is suspected in the pathogenesis of many diseases and age-related
deteriorations. AGE’s can be created endogenously, often as a consequence of excessive blood glucose
levels. AGE’s are also present in browned foods and cured tobacco. As uncontrolled blood glucose levels give
rise to the formation of dangerous AGE’s, it is crucial to maintain blood glucose levels within normal, healthy
limits to avoid excessive AGE induced damage. Maintenance of normal blood glucose levels is fundamental to
preventing AGE formation. Chromium is an integral component of the glucose tolerance factor (GTF), a
naturally occurring compound of chromium, nicotinic acid, and amino acids that is essential for proper glucose
metabolism. Adequate chromium nutrition is essential for the formation of GTF and subsequent healthy
metabolism of normal blood glucose levels. Biotin serves as a cofactor of glucose metabolism and induces
glucokinase, an enzyme that encourages cells to retain glucose for energy production rather than release it
into the blood stream. Alpha-lipoic acid appears to enhance glucose use by muscles by augmenting muscle
protein content. Gymnema sylvestre is an Ayurvedic botanical that may assist in the normal regeneration and
repair of healthy pancreatic beta cells. Gymnema may also support healthy intestinal glucose absorption.
Select nutrients help to directly arrest glycation reactions. A derivative of thiamin (vitamin B1), called thiamin
pyrophosphate, and alpha-lipoic acid have both been shown to prevent in vitro AGE production.
Also crucial to controlling AGE formation and subsequent damage is antioxidant protection. Oxidative stress is
closely related to AGE production and is a known contributing factor to many of the same health concerns
thought to be associated with AGE damage. In vitro studies of N-acetyl-L-cysteine have documented inhibition
of glycation induced damage to pancreatic cells. N-acetyl-L-cysteine is a potent antioxidant, serving as an
intracellular precursor of glutathione.
INDICATIONS
Glucoset™ may be a useful dietary supplement for those who wish to support nutritional control of healthy
blood sugar metabolism.
FORMULA (#GST)
Two Vegetarian Capsules contain:
Thiamine (pyrophosphate) ........................................... 50Nmg.
Biotin ............................................................................ 2,500 mcg.
Chromium (ChromeMate® polynicotinate*) ................. 800 mcg.
Alpha-Lipoic Acid** ...................................................... 200 mg.
N-Acetyl-L-Cysteine ..................................................... 500 mg.
Gymnema sylvestre leaf, ............................................. 400 mg.
dried extract, 25% gymnemic acids
* ChromeMate® brand. U.S. Patent Number 4,923,855 InterHealth Co.
** Lipoic Acid used in this product is of the highest quality available and of Italian origin.

SUGGESTED USE
Two capsules, three times daily at the start of a meal, or as directed by physician.
SIDE EFFECTS
No adverse side effects have been reported.
STORAGE
Store in a cool, dry place, away from direct light. Keep out of reach of children.