Healthy Blood Sugar Metabolism
PRODUCT DATA DOUGLAS LABORATORIES® 04/2012
GlucoBrium,™ provided by Douglas Laboratories, supplies a synergistic combination of Gymnema sylvestre,
fenugreek and cinnamon extracts designed to support healthy blood sugar metabolism.
Glucose metabolism that is associated with abnormally high blood glucose can lead to high levels of glycation.
Glycation is the non-enzymatic attachment of sugars to major molecules in the body, including proteins, lipids,
and nucleic acids. Glycation reactions generate advanced glycation end-products (AGEs) and glycotoxin
intermediates. AGEs cause abnormal and destructive functioning of body proteins, lipids, and nucleic acids.
AGE-associated damage is suspected in the pathogenesis of many diseases and age-related deteriorations.
Gymnema sylvestre is an Ayurvedic botanical that may assist in the normal regeneration and repair of healthy
pancreatic beta cells. Gymnema is also suspected of reducing intestinal glucose absorption. Native to India,
this woody, climbing plant has been used traditionally in India to treat madhu meha, or “honey urine.”
Gymnemic acid, an active component of Gynema sylvestre, has been identified in numerous animal studies as
having anti-hyperglycemic effects. Human studies have indicated it may be useful in healthy glucose
metabolism. Fenugreek, a popular spice in Asia and Europe, contains a high percentage of mucilage, a soluble
dietary fiber. Soluble dietary fiber plays important roles in the digestive system, helping to inhibit the absorption
of sugars and fats and causing blood sugar levels to rise at a slower rate. In studies using diabetes-induced
rats, preparations of fenugreek caused a reduction in postprandial elevation in blood glucose, mainly by
delaying the digestion of sucrose. Other animal studies indicate that the active ingredient, 4-hydroxyisoleucine,
may also play important roles in supporting pancreatic beta-cells during insulin secretion. Human studies have
also indicated that fenugreek plays supportive roles in blood sugar and cholesterol metabolism.
Recently, cinnamon, a well-known spice and flavoring, has been gaining attention for its roles that it plays in
supporting the body’s metabolism of glucose. In one study, patients given cinnamon showed significant
decreases in fasting glucose, triglycerides and cholesterol. Another study has indicated that cinnamon may be
a strong potentiator of insulin. Interestingly, while preliminary studies have identified methyl hydroxyl chalcone
polymer(MCHP) as the primary active ingredient, more recent studies have indicated that this molecule may
have been incorrectly identified. The active ingredients are now believed to be primarily water-soluble
proanthocyanidin type-A polymers. Since proanothocyanidins have excellent antioxidant potential, cinnamon
may offer both the benefits of supporting blood sugar metabolism, as well as providing significant antioxidant
protection to the cell. While the safety of whole cinnamon spice is well known, there is some concern that long
term use of amounts greater than that used in cooking may lead to potential toxic buildup. GlucoBrium
contains Cinnulin PF™, a patented water-soluble cinnamon extract that is processed using a unique extraction
method to remove any potential toxins that whole cinnamon may contain.
GlucoBrium may be a useful dietary supplement for individuals wishing to support healthy blood sugar
metabolism with this unique blend of ingredients.
1 Vegetarian Capsule contains:
Standardized Gymnema extract .................................. 200 mg
(40% gymnemic acids, leaf)
Fenugreek extract ....................................................... 125 mg
(standardized to 20% 4-hydroxyisoleucine)
Cinnamon Extract(Cinnulin PF)™ ................................ 125 mg
Adults take 1-2 capsules daily with meals or as directed by physician.
No adverse side effects reported.
Store in a cool, dry place, away from direct light. Keep out of reach of children
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